Sphere Lock

Sphere Lock is an effect that invalidates all sphere effects on the target. Currently, this effect is exclusive to enemy skills.

Sphere Lock cannot be cleansed by any means outside purging them.

Arena
While not implemented as a buff, Sphere Lock effects can passively appear in Arena as one of the Random Rules, provided the Random Rules option is toggled on.

Elemental Synergy: Nova
Sphere Locks can be negated and purged through the use of the Elemental Synergy, Nova.